Since the late 1970s, when the pathogenic effects of Clostridium difficile were first recognized, infection with this agent has been problematic to patients and a challenge to health care providers for accurate diagnosis, treatment, and containment of illness. Additionally, C difficile–associated infection appears to be increasing in incidence and severity. Which diagnostic techniques and therapeutic options are currently considered most effective? And how can antibiotic stewardship and proper isolation help prevent the onset and spread of this potentially deadly illness?
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