Sprains, strains, and overuse are terms commonly used to explain away subjective complaints of wrist pain caused by occupational and recreational activities. These general descriptors may inadvertently delay healing of a wrist injury because they fail to target the actual cause or specific site of pain. Familiarity with the internal wrist structures and associated musculoskeletal function is essential to the appropriate assessment of wrist pain. Accurate diagnosis optimizes treatment and may prevent a chronic painful condition.