With November 2012 bringing the American Cancer Society’s 37th Great American Smokeout, nearly one-fifth of Americans continue to smoke cigarettes. The unmet tobacco-related goals of Healthy People 2010 have had to be reintroduced in hope of greater success for 2020. The primary care clinician must be aware of all the resources available to help smoking patients quit—and mindful of the clinician’s own role in that important effort.