Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prevention of CVD in Adults with Type 2 Diabetes

AHA/ADA provides updated scientific statement

The American Heart Association (AHA) and the American Diabetes Association (ADA) issued a scientific statement updating recommendations for cardiovascular disease prevention in adults with type 2 diabetes mellitus. Recommendations include:

• Lifestyle modification, including increased physical activity through increased daily physical activity and aerobic exercise

• Nutrition education – DASH, Mediterranean, low-fat, or monitored carbohydrate diets

• Control of Obesity – Caloric restriction and behavioral counseling to comply with dietary recommendations. Pharmacologic and surgical approaches may be considered for patients who do not respond to lifestyle interventions.

• Glucose Control – A1c <7.0% for most patients, with goal individualized based on patients duration of diabetes and comorbidities.

• Avoidance of hypoglycemia

• Aspirin – Low-dose aspirin (75-162 mg daily) is “reasonable” if 10-year risk of coronary disease is greater than 5%, with the evidence being stronger for risk >10%.

• Blood Pressure – Goal < 140/90

• Cholesterol - Patients aged 40 to 75 years with LDL between 70 and 189 mg/dL should be treated with a moderate-intensity statin, and a high-intensity statin should be used if estimated 10-year risk of coronary disease is > 7.5%.

Citation: Fox CS, Golden SH, Anderson C, et al. Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence. Circulation. [Published online ahead of print August 5, 2015]. doi: 10.1161/CIR.0000000000000230.

Commentary: Cardiovascular disease is the most common cause of death in patients with diabetes1. This guideline collates the harmonized recommendations of the AHA and the ADA in one place and serves and a nice review and reminder of the importance of cardiovascular disease prevention in patients with diabetes, with a detailed review of the evidence for those who are interested in reading further. —Neil Skolnik, MD

1. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation. 2013;127:143–152. doi: 10.1161/CIR.0b013e318282ab8f.